The Nerazzurri engineered a late turnaround when the sides last faced off in September and remain three points above their opponents with two games to play.
Having returned to winning ways in Serie A with a 3-0 win over Frosinone at the weekend, Luciano Spalletti will now be looking to get the job done on the European stage with a game to spare.
Ahead of Wednesday night's clash in the English capital, Sports Mole looks at how Inter could line up.
Sime Vrsaljko is part of Inter's travelling party and is expected to be given the nod to return to right-back following his absence against Frosinone with a biceps injury.
That will be a major boost for Spalletti, who will otherwise use Danilo D'Ambrosio in that position should he deem it unnecessary to risk Vrsaljko.
The back four and goalkeeper will otherwise remain unchanged, while in defensive midfield Matias Vecino - on the scoresheet in the reverse meeting - and Marcelo Brozovic have started all four of Inter's previous Champions League games, and there is no reason for that to change here.
Three of the four other positions in the side also effectively pick themselves, though Spalletti must choose between Mauro Icardi and Keita Balde on the left of his three-man attacking midfield, with the latter being preferred in the Nerazzurri's most recent outing.