With Belgium aiming to repeat their World Cup quarter-final win over Spain some 40 years ago, the European nations are set to lock horns in Los Angeles.
Ahead of Friday's big game, the Red Devils received cruel injury news about a key midfielder, while La Roja's squad is not at its full complement either.
Here, Sports Mole rounds up the latest team news for both sides.
SPAIN vs. BELGIUM
SPAIN
Out: Yeremy Pino (collarbone)
Doubtful: Nico Williams (adductor)
Sports Mole's predicted XI: Simon; Porro, Cubarsi, Laporte, Cucurella; Rodri, Pedri; Yamal, Olmo, Baena; Oyarzabal
BELGIUM
Out: Amadou Onana (ACL)
Doubtful: Zeno Debast (leg)
Sports Mole's predicted XI: Courtois; Castagne, Ngoy, Mechele, De Cuyper; Vanaken, Tielemans; Lukebakio, De Bruyne, Trossard; De Ketelaere