They come up against a Fulham side who will be buoyed by their recent 4-1 win away to Crystal Palace on Monday night.
The Saints are currently sixth in the Premier League and are unbeaten in their last five games, including three wins.
Fulham have won their last two and appear to be finding form, and a win could see them move into the top half.
Southampton do not have any further injury or suspension concerns, while Brede Hangeland is a doubt for the Whites having come off at half time against Palace.
Possible starting lineups
Southampton: Boruc; Clyne, Fonte, Lovren, Shaw; Schneiderlin, Wanyama; Lallana, David, Rodriguez; Osvaldo
Fulham: Stekelenburg; Riether, Senderos, Amorebieta, Richardson; Sidwell, Parker; Ruiz, Berbatov, Kasami; Bent
Sports Mole says: 2-0