The Bluebirds have seen their lead at the top of the table cut to four points in the past few weeks with one win from five games.
Wednesday are sure to have one eye on the relegation zone ahead of the match as two losses from their last three outings have left them four points above the drop zone.
Possible starting lineups
Wednesday: Kirkland; Buxton, Johnson, Gardner, Llera; Antonio, Helan, Pugh, Lee; Prutton, Lita
Cardiff: Marshall; Taylor, McNaughton, Connolly, Nugent; Whittingham, Conway, Noone, Gunnarsson; Smith, Campbell
Sports Mole says: 1-2