The Blades will head into the League One clash placed at the foot of the table with five points from 11 matches.
"It will be a tough game against Port Vale," he told reporters at a press conference. "But playing at Bramall Lane will give us a lift and we can also get the support of the crowd.
"However, Port Vale will work hard and make it difficult for us to break."
Port Vale are currently 12th in the league table.