The hosts have not lost on home soil in any competition since August last year, while the visitors have lost two of their last three games on the road.
Shamrock Rovers saw their 13-game unbeaten league run come to an end when they suffered a surprise 1-0 loss away at Drogheda United on Monday.
Despite that loss, Shamrock's nearest challengers Derry City also suffered defeat, their third in succession, meaning Stephen Bradley's side still boast a seven-point lead at the top of the table at the halfway stage.
Shamrock will now prepare for Friday's fixture at the Tallaght Stadium, and they will be confident of returning to winning ways as they are unbeaten in each of their last 21 competitive fixtures on home soil.
Shelbourne, meanwhile, have managed to steer themselves 14 points clear of the bottom two courtesy of an impressive four-game winning streak.
Victories over Sligo Rovers, Drogheda and St Patrick's Athletic were followed by a 2-0 win at home to UCD on Monday.
Damien Duff's men will now look to continue their strong run of form in a bid to remain in the hunt for a top-three finish. Seven points currently separate them from Dundalk in third at the halfway stage.
Success on Friday could prove challenging for Shelbourne, however, as they have failed to win any of their last eight competitive meetings against Shamrock, including six defeats.
As for Shelbourne, Arsenal loanee Jordan McEneff and Adam Thomas are both doubtful with knocks and will be assessed ahead of kickoff, while Brian McManus (foot), Sean McSweeney and Daniel Hawkins (both muscle) all remain sidelined with injuries.
Shamrock Rovers possible starting lineup:
Mannus; Gannon, Hoare, Grace; Cotter, Towell, Watts, Lyons; Byrne, Finn; Burke
Shelbourne possible starting lineup:
Clarke; O'Driscoll, Kane, Griffin, Byrne; Moylan, Lunney, Devlin, Farrell; Carr, Boyd
We say: Shamrock Rovers 2-1 Shelbourne
While the momentum is with Shelbourne heading into Friday's fixture, league leaders Shamrock are still the favourites to come out on top in front of their own supporters.
Bradley's men will be fired up to make amends for Monday's defeat and with almost a full squad to choose from, they should have enough quality to edge past the Reds.
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