The home side dominated the contest from the very first whistle, although it took them until the 28th minute to break the deadlock. Defender Coke Andujar was the scorer, after he fired a loose ball into the net from inside the penalty area.
Zaragoza's chances of collecting a positive result were hampered further four minutes later when Serbian defender Stefan Babovic was given his second caution of the match, leaving his team to play more than a half of the match with a man light.
Sevilla made the numerical advantage count after the restart as Coke claimed his second of the encounter from distance with 53 minutes played.
In a rare venture forward shortly after former Tottenham Hotspur striker Helder Postiga struck the crossbar for Zaragoza, who had struggled up until that point with 10 men.
The match was eventually put beyond the away side shortly after the hour mark when Jose Antonio Reyes curled the ball into the net from 18 yards out, before Alvaro Negredo added a fourth in the 69th minute.