Huesca have very much been the draw specialists in Spain's top flight this season, sharing the points in seven of their 10 matches, suffering just three defeats in the process.
Michel's side are the only La Liga team yet to pick up a victory in 2020-21, though, and currently sit down in 19th spot in the table, level on points with 20th-placed Celta Vigo.
The fact that last season's Segunda Division champions have only suffered three league defeats this term is certainly a positive but their winless run will be a concern.
Huesca lost 4-1 to Real Sociedad and Real Madrid in the latter stages of October but have picked up two points from their last two matches against Eibar and Osasuna and will be hoping that Sevilla's midweek Champions League fixture will leave them lacking energy during Saturday's affair.
Sevilla booked their spot in the last-16 stage of the Champions League on Tuesday night courtesy of a 2-1 victory over Krasnodar, and Lopetegui's side will now battle Chelsea for first spot in the section.
The Europa League holders have had their problems in La Liga this season and actually lost three straight matches to Granada, Eibar and Athletic Bilbao between October 17 and October 31.
Lopetegui's team returned to winning ways at home to Osasuna on November 7, though, before beating Celta 4-2 last weekend to rise into the top half of the division.
Los Nervionenses are currently seventh in Spain's top flight, just four points behind fourth-placed Real Madrid with a game in hand, and they will certainly be looking for another Champions League finish.
Sevilla will be desperate to pick up another positive result ahead of their next league fixture against the reigning champions on December 5, but the fact that they have had a long trip back from Russia could harm their preparations for Saturday's contest at Estadio El Alcoraz.
Huesca La Liga form: DDLLDD
Sevilla La Liga form: DLLLWW
Sevilla form (all competitions): WLWWWW
As for Sevilla, Jesus Navas was suspended for the Champions League clash with Krasnodar, but the experienced Spaniard should return to the starting XI on Saturday.
Huesca possible starting lineup:
Fernandez; Lopez, Insua, Siovas, Galan; Ferreiro, Rico, Mosquera, Garcia; Sandro, Mir
Sevilla possible starting lineup:
Vaclik; Navas, Kounde, Carlos, Escudero; Rakitic, Fernando, Jordan; El Haddadi, En-Nesyri, Ocampos
We say: Huesca 1-2 Sevilla
Huesca have only lost three of their 10 league matches this season and have proved difficult to break down on occasions. Sevilla are on an impressive run of wins, though, and we fancy Lopetegui's side to make it five straight victories in all competitions with a narrow success at Estadio El Alcoraz.