Sevilla closed in on Champions League qualification as they won 2-0 against Real Mallorca at the Estadio Ramon Sanchez Pizjuan.
A fourth successive LaLiga win for Julen Lopetegui's fourth-placed men leaves them level on points with third-placed Atletico Madrid and nine clear of Villarreal in fifth, who host Real Sociedad on Monday.
Mallorca, meanwhile, have dropped a place to second-bottom in the table – they are three points adrift of safety.
Having managed to see out the win despite being reduced to 10 men by a red card for Jonathan Silva early in the second half, Javier Aguirre's side are also three points behind 17th-placed Alaves, who are another side in action on Monday when they host Getafe.
Eibar won 2-0 at already-relegated basement boys Espanyol and are now guaranteed to survive, lying seven points clear of the drop zone in 15th place.
Theo Hernandez put the visitors ahead in the 20th minute, Napoli turned things around with goals from Giovanni Di Lorenzo and Dries Mertens and Franck Kessie then levelled with a penalty in the 73rd minute, before Milan substitute Alexis Saelemaekers was sent off late on.
Genoa rose out of the relegation zone with a 2-0 home win against rock-bottom SPAL. Goran Pandev (24) and Lasse Schone (54) scored either side of Iago Falque having a penalty saved by SPAL goalkeeper Karlo Letica.
Moving from 18th to 17th, Genoa swapped places with Lecce, who drew 0-0 at Cagliari – the gap between the teams is a point.
Sampdoria came from behind to beat Udinese 3-1 at the Dacia Arena, putting them on the same amount of points their hosts, six clear of the relegation zone.
On-loan Wolves striker Patrick Cutrone scored a late equaliser for Fiorentina after Hellas had led through Davide Faraoni.
And there was an even more dramatic conclusion at the Stadio Ennio Tardini as Parma scored twice in additional time to force a 2-2 draw, with Jasmin Kurtic netting a header and Roberto Inglese adding a finish moments later.
Bologna had been 2-0 up by the 16th minute thanks to efforts from Danilo and Roberto Soriano.