Kevin Gameiro has been handed the lone centre-forward's role for Sevilla's Europa League semi-final second leg clash against Shakhtar Donetsk.
There had been talk that Fernando Llorente would be given the responsibility, but head coach Unai Emery has put his faith in Gameiro.
Elsewhere, Yevhen Konoplyanka has dropped down to the bench, which means that Coke will play out wide on the right.
There will be no Michael Krohn-Dehli or Jose Antonio Reyes, though, as both players are ruled out through injury.
As for the visiting Ukrainians, ex-Arsenal striker Eduardo da Silva has come into the attack at the expense of Facundo Ferreyra.
Sevilla: Soria; Coke, Rami, Carrico, Tremoulinas; N'Zonzi, Krychowiak; Vitolo, Banega, Mariano; Gameiro
Subs: Rico, Iborra, Cristoforo, Escudero, Pareja, Konoplyanka, Llorente
Shakhtar Donetsk: Pyatov; Srna, Kucher, Rakitskiy, Ismaily; Malyshev, Stepanenko, Kovalenko; Taison, Eduardo, Marlos
Subs: Kanibolotskyi, Ordets, Kobin, Wellington Nem, Dentinho, Bernard, Ferreyra
Follow Sports Mole's live text coverage of the game at the Ramon Sanchez Pizjuan Stadium here.
Liam Apicella
