Both teams had chances to add to the scoring in an end-to-end second period, but the score remained 2-0 ahead of the second leg at the Mestalla next week.
Read how it all unfolded in Sports Mole's minute-by-minute live commentary of the action below.
SEVILLA: Beto; Diogo, Pareja, Fazio, Navarro; Carrico, Mbia; Reyes, Rakitic, Vitolo; Bacca
VALENCIA: Guaita; Pereira, Fuego, Mathieu, Bernat; Keita, Parejo; Feghouli, Fede, Vargas; Alcacer
42 - Sevilla (top with 23) and Valencia (19) are two of the top four scoring sides in the UEFA Europa League this season. Potent.— OptaJose (@OptaJose) April 24, 2014