Bremen, who occupy 17th spot in the table, have picked up four points from their last two matches, but Schalke have lost each of their three games since the Bundesliga resumed on May 16.
Schalke's search for their first Bundesliga win since the middle of January will continue this weekend, and there is no question that the club's supporters will be looking for their side to bounce back as soon as possible.
Not since a 2-0 success at home to Borussia Monchengladbach on January 17 have Schalke collected all three points in the league, while they have now lost five of their last six in Germany's top flight.
David Wagner's side played out a 1-1 draw with Hoffenheim before the Bundesliga was called to a halt in March, but Die Konigsblauen have lost each of their three matches since the action resumed on May 16.
Indeed, a 4-0 defeat to Borussia Dortmund was followed by a 3-0 reverse at home to Augsburg, before they suffered a 2-1 defeat at struggling Fortuna Dusseldorf on Wednesday night.
Schalke are still ninth in the table but have now fallen five points off sixth-placed Wolfsburg in the race for a Europa League spot, meaning that a positive result this weekend is vital.
Bremen remain in a difficult position in the table, with a total of 22 points from 27 matches leaving them 17th position, six points behind 15th-placed Mainz 05.
Florian Kohfeldt's side have a game in hand over every side in the division other than Eintracht Frankfurt, though, and have picked up four points from their last two matches.
Indeed, a 1-0 success over Freiburg on May 23 was followed by a goalless draw at home to Borussia Monchengladbach on Tuesday night, which could be two big results in their fight for survival.
Bremen's game in hand against Frankfurt is next Wednesday, and a positive result against Schalke in this match would lead them nicely into what is a six-pointer at the bottom of the table.
Die Werderaner have not operated outside of the Bundesliga since the 1980-81 campaign, but the team are certainly in a battle to secure their top-flight status this season.
Schalke Bundesliga form: LLDLLL
Schalke form (all competitions): LLDLLL
Werder Bremen Bundesliga form: LLDLWD
Werder Bremen form (all competitions): LLDLWD
Schalke will again be without the services of Omar Mascarell and Benjamin Stambouli through injury, but Amine Harit and on-loan Barcelona centre-back Jean-Clair Todibo could both return to the starting XI.
Ozan Kabak made his return from a back injury against Dusseldorf during the week, but Todibo could be handed a spot in the first XI after featuring late on in the same match.
Schalke possible starting lineup:
Schubert; Nastasic, Todibo, Sane; Kenny, McKennie, Schopf, Oczipika; Matondo, Burgstaller, Caliguiri
Werder Bremen possible starting lineup:
Pavlenka; Gebre Selassie, Veljkovic, Moisander, Freidl; Klaassen, Eggestein, Bartels; Rashica, Sargent, Bittencourt
We say: Schalke 1-1 Werder Bremen
Schalke have really struggled since the return of Bundesliga action, and it is therefore difficult to back the hosts with any real confidence despite Bremen's issues this season. The visitors have actually won on their last two trips to Schalke in the league, but we fancy a low-scoring draw on Saturday afternoon.