The 21-year-old was left out of Friday's World Cup qualifier against Finland and will now miss the international friendly against Chile on Tuesday.
After undergoing tests, the Los Blancos star will return to the Spanish club to continue his recovery.
Isco arrived at the Santiago Bernabeu from Malaga this summer for a fee of €30m (£25.2m).
Restore Data
| Team | P | W | D | L | F | A | GD | PTS | |
| C | Real Madrid | 35 | 28 | 6 | 1 | 78 | 22 | 56 | 90 |
| 2 | Barcelona | 35 | 23 | 7 | 5 | 72 | 43 | 29 | 76 |
| 3 | GironaGirona | 35 | 23 | 6 | 6 | 75 | 44 | 31 | 75 |
| 4 | Atletico MadridAtletico | 35 | 22 | 4 | 9 | 64 | 39 | 25 | 70 |
| 5 | Athletic Bilbao | 35 | 17 | 11 | 7 | 57 | 35 | 22 | 62 |
| 6 | Real BetisBetis | 35 | 14 | 13 | 8 | 46 | 41 | 5 | 55 |
| 7 | Real Sociedad | 35 | 14 | 12 | 9 | 48 | 37 | 11 | 54 |
| 8 | Valencia | 35 | 13 | 9 | 13 | 37 | 39 | -2 | 48 |
| 9 | Villarreal | 35 | 13 | 9 | 13 | 59 | 60 | -1 | 48 |
| 10 | Getafe | 35 | 10 | 13 | 12 | 41 | 48 | -7 | 43 |
| 11 | AlavesAlaves | 35 | 11 | 9 | 15 | 34 | 40 | -6 | 42 |
| 12 | Sevilla | 35 | 10 | 11 | 14 | 47 | 49 | -2 | 41 |
| 13 | Osasuna | 35 | 11 | 7 | 17 | 39 | 53 | -14 | 40 |
| 14 | Las PalmasLas Palmas | 35 | 10 | 7 | 18 | 30 | 44 | -14 | 37 |
| 15 | Mallorca | 35 | 7 | 14 | 14 | 28 | 40 | -12 | 35 |
| 16 | Rayo Vallecano | 35 | 7 | 14 | 14 | 27 | 43 | -16 | 35 |
| 17 | Celta Vigo | 35 | 8 | 10 | 17 | 40 | 53 | -13 | 34 |
| 18 | CadizCadiz | 35 | 5 | 14 | 16 | 24 | 49 | -25 | 29 |
| R | Granada | 35 | 4 | 9 | 22 | 36 | 68 | -32 | 21 |
| R | Almeria | 35 | 2 | 11 | 22 | 35 | 70 | -35 | 17 |
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