The Argentinian has netted 14 times this season, but Sanchez has said that the club does not intend to keep both Higuain and Karim Benzema.
"At a great club like Real, we believe we need two number nines of a high level," Sanchez told L'Equipe.
"We have Benzema and Higuain. Higuain will leave, Benzema will stay and two others will come."
Real face Real Valladolid on Saturday.