The skipper has missed Los Blancos' last three games due to a broken nose but is passed fit tonight as the side look to capitalise on Barcelona's slip-up earlier today, which saw the league leaders drop two points at home to Celta Vigo.
Ramos replaces Jesus Vallejo at the heart of defence alongside Raphael Varane, with Dani Carvajal at right-back and Marcelo on the left as Zinedine Zidane makes three changes from the 3-2 league victory over Malaga last weekend.
As for the hosts, who are now without a win in five league games, under-pressure boss Cuco Ziganda makes two changes from the 2-2 draw at Deportivo La Coruna last weekend.
Mikel Rico and Ander Iturraspe play in a holding partnership, while Xabier Etxeita comes into the back four alongside Oscar de Marcos, Mikel Balenziaga and Unai Nunez as Eneko Boveda and Aymeric Laporte drop out.
Athletic Bilbao: Kepa; De Marcos, Etxeita, Nunez, Balenziaga; Iturraspe, Mikel Rico; Williams, Raul Garcia, Susaeta; Aduriz
Subs: Herrerin, Boveda, Mikel San Jose, Lekue, Merino, Aketxe, Cordoba
Real Madrid: Keylor Navas; Carvajal, Ramos, Varane, Marcelo; Modric, Casemiro, Kroos; Isco; Benzema, Ronaldo
Subs: Casilla, Ceballos, Nacho, Hernandez, Kovacic, Vazquez, Mayoral
Keep up with all of the action from San Mames this evening with Sports Mole's live text commentary here.