Jose Mourinho's men failed to find the net in their last league clash as they missed Cristiano Ronaldo due to suspension, and the Spanish giants are becoming increasingly frustrated after dropping 18 points adrift of leaders Barcelona in the table.
Meanwhile, Valencia sit just below the European places and considering Madrid's recent results, the home side may feel that they can get a win, which could push them towards the top four.
Ronaldo is expected to return to the starting lineup, while Gonzalo Higuain should be named in the side to provide an attacking threat for the visitors.
Real Madrid: LWWDL
Possible starting lineups
Valencia: Alves; Rami, Pereira, Costa; Albelda, Banega, Guardado, Parejo; Jonas, Soldado, Piatti
Real Madrid: Casillas; Varane, Coentraro, Arbeloa, Albiol; Khedira, Alonso, Modric, Ronaldo; Di Maria, Higuian
Sports Mole says: 1-2