Las Palmas make the trip to the Bernabeu having suffered defeat in their last six matches in Spain's top flight, although La UD did manage a victory over Deportivo La Coruna in the Copa del Rey.
Real Madrid are not used to suffering one defeat, never mind two in a row, but Zinedine Zidane could not have asked for a better game to get his star-studded squad back on track both in the short term and in the La Liga title race.
Even at this stage, a gap of eight points to Barcelona may be difficult to overcome but Los Blancos can forget any talk of a successful defence of their crown until they show signs of making improvements from the defeats at both Girona and Tottenham Hotspur.
Cristiano Ronaldo has argued that Real did not deserve to lose either fixture due to offside goals and while the Portuguese superstar may have a case, Zidane will be more concerned by the lack of reaction from a group of players who completed the La Liga and Champions League double last season.
Only the players will know if motivation is a factor or whether the team are just going through a transitional period with Achraf Hakimi being required at right-back and expectation levels rising where Marco Asensio is concerned, but Real desperately require a win ahead of the derby with Atletico after the international break.
Ronaldo desperately needs to improve in La Liga, too, with the 32-year-old only contributing one goal and one assist from six starts in the league this season, although the forward does have six strikes in the Champions League.
Real will take heart from their last two home matches in the league being won with minimal fuss, but there may be a different atmosphere at the Bernabeu this weekend and Real need Ronaldo to lead from the front.
Recent form: LWWWWL
Recent form (all competitions): WDWWLL
Las Palmas are one of the few teams in La Liga who managed to gain a point or more at the Bernabeu last season, but it is fair to say that they face an uphill task on Sunday, despite the form of their hosts.
Back-to-back victories over Malaga and Athletic Bilbao in September had suggested that the top-flight minnows could enjoy a solid season, but two defeats were followed by the resignation of Manuel Marquez Roca, and Pako Ayestaran has struggled to halt the slump in his opening five weeks in charge.
The former Liverpool assistant has witnessed his side concede 15 goals in four league matches - although two of those matches were at Barcelona and Villarreal - and there will be feelings of trepidation ahead of one of world football's stiffest tests.
However, in attack, Loic Remy could provide Las Palmas with some much-needed hope. The 30-year-old left Chelsea to link up with the Gran Canaria-based club and has been somewhat of a revelation since August, scoring four goals in his first 272 minutes.
The French international has started just one game - the 3-1 defeat at Deportivo on Monday - but a seventh-minute effort should mean that he has moved himself above Jonathan Calleri in the pecking order ahead of a game when Ayestaran may have to opt for a more defensive lineup.
Las Palmas have players in Alberto Aquilani, Jonathan Viera and Vitolo who can really change the game going forward but Las Palmas will not make inroads up the table until the defence tightens up, and that must start on Sunday night.
Recent form: LLLLLL
Recent form (all competitions): LLLLWL
However, Remy should get the nod in attack, with Ayestaran having a decision to make over whether he begins on the flank or as the team's number nine.
Real Madrid possible starting lineup:
Casilla; Hakimi, Ramos, Varane, Marcelo; Casemiro, Modric, Kroos; Isco, Ronaldo, Benzema
Las Palmas possible starting lineup:
Raul; Lemos, Michel, Bigas, D.Castellano, Gomez, Samper, Aquilani, Vitolo, Remy, Calleri
Head To Head
Since Las Palmas earned a return to the top flight in 2015, Real have come through their games with the minnows having not lost in four matches, but that does not tell the whole story.
However, Real have managed to score a remarkable total of 18 goals in just four home fixtures with Las Palmas.
We say: Real Madrid 3-0 Las Palmas
Talk about perfect games at the perfect time. After back-to-back defeats, Real will welcome the chance to host a team who have lost six in a row and it should be plain sailing for the current champions, who could also do with improving their goal difference.