Los Blancos currently top the table with 10 points from their first four league matches of the season, while Cadiz occupy ninth position with seven points from their five outings this term.
Madrid opened their La Liga season with a goalless draw at Real Sociedad on September 20 but have put three victories on the board since, overcoming Real Betis, Real Valladolid and Levante.
Not too much can be read into the league table at this stage of the season, but Los Blancos are leading from the front and will fancy their chances of putting another three points on the board this weekend.
It is a big week for Zinedine Zidane's side considering that they will open their 2020-21 Champions League challenge at home to Ukrainian outfit Shakhtar Donetsk on Wednesday before the small matter of a trip to Barcelona for the first Clasico of the season next weekend.
The financial impact of the coronavirus outbreak meant that it was a very quiet summer for the club, and there is a lot of pressure on the likes of Karim Benzema and Sergio Ramos to lead the team once again.
Madrid have not actually faced Cadiz since the 2005-06 La Liga season, and the capital giants won both games during that particular campaign, including a 3-1 success on home soil.
Cadiz finished second in last season's Segunda Division to secure a return to this level of football for the first time since being relegated in 2006.
Cadiz opened their La Liga campaign with a 2-0 defeat to Osasuna on September 12 before recording a 2-0 victory away to Huesca on September 20 to secure an important three points.
The team's second league defeat of the campaign arrived at home to Sevilla one week later, but they recorded an impressive 1-0 victory at Athletic Bilbao at the start of the month before picking up a point against Granada before the international break to move onto seven points, leaving them ninth in the division.
Real Madrid La Liga form: DWWW
Cadiz La Liga form: LWLWD
Eden Hazard is also still unavailable due to a muscular problem, with the Belgium international battling to be available for El Clasico at Camp Nou next weekend.
Marco Asensio is also in line to feature in the final third of the field, with Vinicius Junior potentially being given the nod on the other side of Benzema. Thibaut Courtois, meanwhile, should be fit despite being forced to pull out of the Belgium squad ahead of the UEFA Nations League clash with England.
Real Madrid possible starting lineup:
Courtois; Nacho, Varane, Ramos, Marcelo; Kroos, Casemiro, Isco; Vinicius, Benzema, Asensio
Cadiz possible starting lineup:
Ledesma; Akapo, Mauro, Cala, Espino; Mari, Jonsson; Sanchez, Fernandez, Pombo; Negredo
We say: Real Madrid 2-0 Cadiz
Cadiz have impressed in the early stages of the 2020-21 campaign and picked up an excellent win at Athletic in their last away game on October 1. Madrid are the heavy favourites for a reason, though, and we expect Zidane's side to put a fourth straight La Liga victory on the board.