Osasuna will be looking for three points for very different reasons, as they seek to move away from the relegation zone. Javi Gracia's men sit one point clear of the bottom three after losing four of their last six league games.
Los Rojillos held Malaga to a 3-3 draw in the Copa del Rey last week.
Real Madrid come into the match off the back of their Champions League success over Copenhagen on Wednesday.
Gracia could decide to bring Oriol Riera back into the Osasuna side after the striker missed the draw at Malaga.
Real Madrid: LWWWWW
Possible starting lineups
Osasuna: Fernandez; Bertran, Loties, Arribas, Damia; Cejudo, Lolo, Punal, Armenteros, De las Cuevas; Riera
Real Madrid: Lopez; Pepe, Ramos, Arbeloa, Marcelo; Modric, Alonso; Di Maria, Ronaldo, Bale; Benzema
Sports Mole says: 1-3