The Blaugrana will host the first leg at the Nou Camp, and will head into the game on the back of a 5-1 home victory over Real Sociedad in La Liga on Sunday.
"Madrid have very good players on the break," said Vilanova. "Pepe is a very quick player, who allows the Madrid defence to play more advanced.
"We have to be aware of Madrid's counter attack, but we play at home and everybody knows our strengths."
Barcelona won last year's Super Cup 5-4 on aggregate.