The current Spanish champions travel to the Bernabeu on Sunday currently trailing La Liga leaders Los Blancos by four points with just 10 games remaining.
"Madrid are very difficult to stop on the counter," Alba told reporters.
"We need to be very well closed to that to avoid it because it is vital we win this match. With Pedro, Neymar or Alexis [Sanchez] we play more open and with Iniesta more closed.
"But it doesn't influence me if there are changes and I feel just as good playing with all of my teammates. There are no favourites in a Clasico. It is a precious match to play in, Madrid are a great team and this year they are at a great level. To win the league you have to win at the Bernabeu."
Barcelona were 2-1 winners in the reverse match at the Camp Nou earlier in the season.