Athletic Bilbao vs. Real Madrid (Sunday, 1.00pm)
Los Blancos are currently four points clear of second-placed Barcelona at the summit, while Athletic occupy eighth position, just four points off sixth-placed Getafe in the race for a Europa League spot.
We say: Athletic Bilbao 1-1 Real Madrid
As mentioned, four of the last five La Liga meetings between these two sides have finished level, while Madrid have not won at San Mames in the league since March 2017. Los Blancos are on a roll at the moment, but Athletic are also in impressive form, and we fancy a low-scoring draw on Sunday night.
Espanyol vs. Leganes (Sunday, 4.00pm)
Espanyol are currently 10 points behind 17th position, while Leganes are nine points from safety, with both clubs facing the real possibility of dropping into the Segunda Division.
We say: Espanyol 2-1 Leganes
There is simply no downplaying the importance of this match for both sides; a draw suits neither and therefore it would not be a surprise to see an open game. Espanyol have the worst home record in the league this season, but we fancy the Catalan side to pick up all three points courtesy of a narrow win.
Osasuna vs. Getafe (Sunday, 6.30pm)
Osasuna will be looking to make it four La Liga victories in a row when they welcome top-four challengers Getafe to Estadio El Sadar on Sunday night.
The home side have won their last three in Spain's top flight during a strong run of form, but Getafe have seen their Champions League hopes falter due to a run of just one win in seven matches.
We say: Osasuna 1-1 Getafe
Getafe will be determined to pick up all three points as they battle for a top-four spot, but Osasuna's recent form has been excellent and cannot be ignored; we are expecting a tight match in Pamplona and are ultimately struggling to separate the two sides, tipping a low-scoring draw.
Villarreal vs. Barcelona (Sunday, 9.00pm)
Barcelona will be looking to keep their La Liga title hopes alive when they travel to an in-form Villarreal on Sunday night for what should be a fascinating affair.
The Spanish champions could be seven points off leaders Real Madrid by the time that they take to the field for this match, and Villarreal's recent form is likely to be of concern to the Catalan giants.
We say: Villarreal 1-2 Barcelona
It is a game that Barca simply have to win, and we fancy the champions to emerge victorious. Villarreal have been excellent since the lockdown period, but the Spanish champions must stay in touch with Real Madrid, who have a tough game themselves away to Athletic Bilbao on Sunday afternoon.