Barca have shared the points in three of their last four matches in the league, including a 2-2 draw at home to Atletico Madrid on Tuesday night.
Here, Sports Mole looks at how the Catalan giants could line up against the Yellow Submarine.
Barca will again be without the services of Frenkie de Jong and Ousmane Dembele through injury, while Samuel Umtiti is also unavailable for selection due to a troublesome knee problem.
Antoine Griezmann's late appearance against Atletico on Tuesday night has led to a host of speculation surrounding the Frenchman's future, but the 2018 World Cup winner could be recalled to the starting XI this weekend, potentially joining Luis Suarez and Lionel Messi in the final third of the field.
Riqui Puig could be the player to drop out to allow Griezmann to start, while Ivan Rakitic and Arturo Vidal should keep their spots alongside Sergio Busquets in midfield as Arthur is heading for Juventus this summer.