Zinedine Zidane's side are currently second in Group B, three points clear of third-placed Shakhtar, meaning that a victory would allow them to advance to the knockout round of the competition.
Los Blancos will enter the European match off the back of a disappointing result, though, having suffered a 2-1 home defeat to Alaves in La Liga on Saturday night.
Here, Sports Mole looks at how the visitors could line up in Kiev.
Madrid will again be without the services of Sergio Ramos, Federico Valverde and Dani Carvajal through injury, while Luka Jovic is still unavailable due to a recent positive coronavirus test.
Alvaro Odriozola is also a huge doubt with an ongoing calf problem, meaning that Lucas Vazquez could continue at right-back with Nacho lining up in the middle of the defence, although Eder Militao is also an option, having overcome coronavirus.
Eden Hazard, meanwhile, could miss out with the muscular injury that forced him off against Alaves, which might see Vinicius Junior handed a spot on the left.
Madrid should be boosted by the return of Karim Benzema from a calf issue, though, with the Frenchman set to replace Mariano Diaz through the middle, while Marco Asensio could drop out of the XI to allow Rodrygo Goes to feature on the left.