Los Blancos have been in stunning form since returning to action last month and currently sit four points clear of second-placed Barcelona at the summit with four games left.
Zinedine Zidane's side have won each of their last three in the league 1-0 and will be taking on an Alaves team that sacked their manager last weekend following five straight defeats.
Here, Sports Mole looks at how Madrid could line up at the Alfredo Di Stefano Stadium.
Zidane will be forced to alter his back four for Friday's clash as Sergio Ramos and Dani Carvajal are both suspended due to the yellow cards that they picked up in the 1-0 win over Athletic Bilbao at the weekend.
Nacho is still out with a thigh problem, but Raphael Varane has returned to training following a head injury, and the Frenchman is in line to make a timely return for the capital giants in this match.
Should Mendy be given the nod then Marcelo would come into the side at left-back and that does appear to be the expected outcome as Vazquez has struggled with injury in recent weeks.
There is also a decision to be made in midfield with Toni Kroos starting on the bench against Athletic; Federico Valverde could drop out to allow the German to return for this match, joining Casemiro and Luka Modric.