Diego Simeone's side have made an excellent start to the 2020-21 season, picking up 26 points from their 10 matches to sit at the top of the table, six points clear of fourth-placed Real Madrid with a game in hand.
Atletico will also enter the match off the back of a 2-0 victory over Red Bull Salzburg in the Champions League, which saw them book their spot in the last-16 stage of the competition.
Here, Sports Mole looks at how the visitors could line up this weekend.
Atletico will again be without the services of Jose Gimenez, Diego Costa and Manu Sanchez on Saturday, but the capital giants did not pick up any fresh issues against Salzburg on Wednesday night.
It seems likely that Simeone will again select a 3-5-2 formation for this match, with Luis Suarez joining Joao Felix in the final third of the field. The two forwards have managed 10 league goals between them this season and will provide a real threat to Zinedine Zidane's side in this contest.
Marcos Llorente has been in excellent form for Atletico this season, scoring five times and contributing three assists in 16 appearances, and the Spaniard will line up against his former club.