Thibaut Courtois has sustained a hip injury and will likely miss the rest of the month, leaving Keylor Navas to deputise for the Belgian stopper.
Toni Kroos could be absent for the next three weeks with a thigh problem, and Dani Ceballos may be given another chance in midfield due to fitness issues with both of Marcos Llorente and Marco Asensio.
Solari has been previously against using Isco in the final third, but the playmaker could get the nod over Brahim Diaz with the youngster having only recently joined from Manchester City.
The backline may remain the same, despite Real's supporters growing increasingly impatient with the performances of left-back Marcelo.
Who will win Sunday's La Liga clash between Real Betis and Real Madrid?