With their chances of retaining their La Liga title having all but evaporated, the Champions League and the Copa del Rey are Real Madrid's best chances of adding more silverware to the trophy cabinet this season.
They are the most successful side in the history of the competition and are currently on course to win their 10th European crown.
Didier Drogba is also likely to start for Gala, who have not reached the last four of this tournament since 1989.
These two sides have met on three previous occasions, with Istanbul-based Galatasaray leading Madrid 2-1.
Real Madrid: WWWWWD
Possible starting lineups:
Real Madrid: Lopez; Arbeloa, Ramos, Pepe, Coentrao; Alonso, Khedira; Ozil, Di Maria, Ronaldo; Benzema
Galatasaray: Muslera; Eboue, Kaya, Nounkeu; Sneijder, Altıntop, Melo, Riera, Inan; Drogba, Yılmaz
Sports Mole says: 2-0