If they are to go even further, they will have do so without suspended attacker Gustavo Manduca.
However, former Chelsea midfielder Nuno Morais is expected to be passed fit to take his place in the starting lineup.
Real coach Jose Mourinho has never lost a quarter-final in the Champions League throughout his management career.
R Madrid: WWWDDW
APOEL: Chiotis; Poursaitidis, Jorge, Oliveira, Boaventura; Morais, Marcinho; Charalambidis, Trickovski, Solari; Ailton
R Madrid: Casillas; Arbeloa, Ramos, Pepe, Marcelo; Khedira, Granero; Ozil, Kaka, Ronaldo; Benzema
Sports Mole says: 0-2