Madrid have triumphed in 14 of their last 23 away matches in European competition, though, while they recorded a 6-1 victory over Galatasaray when they last travelled to the Turkish giants in September 2013.
Here, Sports Mole looks at how the capital outfit could line up in Istanbul.
Dani Carvajal and Eden Hazard were both left out of Saturday's clash with Mallorca, with the former rested and the latter given time off following the birth of his fourth child. The duo are set to return on Tuesday night, although head coach Zinedine Zidane will still be without a number of key players.
Marco Asensio and Nacho were always going to be unavailable due to knee injuries, but there was hope that the likes of Lucas Vazquez, Gareth Bale and Luka Modric could be available for the match.
Bale and Modric both missed the clash with Mallorca due to injuries that were picked up over the international break - neither are serious issues, but the pair have not been included in the travelling squad, while the same can also be said for Lucas due to a calf problem.
There is a return for Toni Kroos, though, and the Germany international is expected to line up alongside Federico Valverde and Casemiro in midfield, with Vinicius Junior potentially featuring further forward.
The likes of Sergio Ramos and Karim Benzema will keep their spots, but Zidane is expected to ring the changes with a number of players - including struggling centre-forward Luka Jovic - disappointing in their first league defeat of the season.