The Royals currently occupy sixth spot in the Championship, but Adkins believes that their hopes of securing a place in the playoffs will disappear if they don't hit top form against Burnley, who have already been promoted.
"We're facing a team who's just been promoted, they will come to our place and give us nothing," Adkins told reporters. "We've got to be right at it.
"The mind-set has to be to win. We won our last home game, won on Saturday and showed we can come from behind."
Brighton & Hove Albion and Blackburn Rovers are the two teams in contention to snatch a playoff place away from Reading.