Picking up maximum points on Sunday is vital for both sides as they try to avoid relegation from the top flight before the end of the campaign.
The home side are seven points away from safety with as many matches left to play, while their North-West opponents are only out of the bottom three on goal difference, yet they have a game in hand on their fellow struggling competitors.
QPR boss Harry Redknapp has described this weekend's contest as a "must-win" game for his team following their back-to-back defeats to Fulham and Aston Villa.
In the reverse fixture four months ago, both sides found the net twice to secure a draw at the DW Stadium.
Redknapp will be without winger Shaun Wright-Phillips for the remainder of the season as he recovers from ankle surgery, while Wigan boss Roberto Martinez is expected to start Callum McManaman in attack.
Queens Park Rangers: LLWWL
Wigan Athletic: WWLWL
Possible starting lineups
Queens Park Rangers: Cesar; Bosingwa, Samba, Hill, Traore; Jenas, Mbia; Remy, Taraabt, Townsend; Zamora
Wigan Athletic: Robles; Scharner, Alcaraz, Figueroa; Boyce, McCarthy, Gomez, Beausejour; Maloney, McManaman, Kone
Sports Mole says: 2-1