The hosts have yet to taste defeat in 14 games so far and have also conceded just three goals in seven games at Parc des Princes.
Lyon's form has improved recently and they have taken seven points from their last nine, but now face the toughest match of the league season.
Possible starting lineups
PSG: Sirigu; Van der Wiel; Alex, Silva, Maxwell; Verratti, Motta, Matuidi; Lavezzi, Cavani, Ibrahimovic
Lyon: Vercoutre; Lopes, Bisevac, Umtiti, Bedimo; Malbranque, Gonalons, Fofana; Grenier; Lacazette, Briand
Sports Mole says: 2-0