Twenty-five points separate league leaders PSG from their opponents - eight more than Amiens have accumulated so far this term.
PSG have had a typically dominant season so far, seven points clear at the top of the Ligue 1 table and winning their Champions League group.
In all competitions, they have won their last five, are unbeaten in their last nine and have won a total of 20 of their 24 games.
In their last three games, the reigning French champions have scored at least four goals on each occasion, conceding only once in that run.
Tuchel's side are comfortably the top scorers in Ligue 1, with their tally of 39 goals from just 17 games 11 ahead of their nearest challengers in Bordeaux and Lyon, who have both played a game extra.
PSG also boast the joint-best defensive record in the league, level on just nine conceded with Reims - a fearsome opponent for Amiens.
The struggling outfit, by comparison, have the second-worst defensive record in the division, with their 32 goals conceded ahead of only bottom-of-the-league Toulouse.
Amiens are also winless in their last five league games, with their 1-1 draw against Dijon in their most recent league game putting an end to a four-game losing run.
Paris Saint-Germain Ligue 1 form: LWWWWW
Paris Saint-Germain form (all competitions): DWWWWW
Amiens Ligue 1 form: WLLLLD
Amiens form (all competitions): LLLLDW
PSG head coach Thomas Tuchel is without a handful of central players for this one but certainly does not lack the squad depth to deal with that.
Edinson Cavani is also a doubt, but Tuchel has plenty of attacking options at his disposal and the Uruguayan has slipped down the pecking order in any case.
Amiens boss Elsner also has four players likely to be unavailable for the trip to Paris.
Paris Saint-Germain possible starting lineup:
Navas; Meunier, Silva, Marquinhos, Bernat; Paredes, Verratti; Di Maria, Neymar; Mbappe, Icardi
Amiens possible starting lineup:
Gurtner; Calabresi, Chedjou, Dibassy, Lefort; Blin, Gnahore; Akolo, Kakuta, Diabate; Konate
We say: Paris Saint-Germain 3-0 Amiens
All the signs point to a comfortable, routine win for the Ligue 1 leaders. They are in fine form and are lethal going forward, up against a struggling side with a poor defensive record.