The playmaker sustained a thigh injury while on international duty with Italy, and while his issue is not thought to be anything serious, Mauricio Pochettino is expected to let him rest ahead of Wednesday's Champions League quarter-final first leg with Bayern Munich.
However, Neymar was fit enough to appear as a substitute in the recent win over Lyon and will be eyeing a return to the starting lineup here, while Kylian Mbappe became the youngest player to hit 100 Ligue 1 goals at 22 years and 91 days following his brace against Les Gones.
With Danilo Pereira also nursing a minor calf problem, Leandro Paredes should return to partner Idrissa Gueye in the midfield, unless Pochettino opts to call upon fresher legs in the form of Ander Herrera.
Marquinhos is in line for his 200th Ligue 1 appearance for PSG this weekend and would become only the second player to hit that milestone for the club - following in the footsteps of his former mentor Thiago Silva - and the Brazilian will likely partner Presnel Kimpembe once more.
Layvin Kurzawa had reclaimed his spot at left-back earlier in the season, but Abdou Diallo has enjoyed some stellar performances in that role recently and is surely in no danger of dropping out, especially with Kurzawa nursing a calf injury.
PSG possible starting lineup:
Navas; Florenzi, Marquinhos, Kimpembe, Diallo; Gueye, Paredes; Di Maria, Rafinha, Neymar; Mbappe