The defending champions have won eight from eight to already soar eight points clear of the chasing pack, and also got off the mark in the Champions League on Wednesday with a thumping 6-1 win over Red Star Belgrade.
Sunday sees them host a Lyon side currently sitting fifth, but unbeaten in six games across all competitions, including an away triumph over Manchester City.
Here, Sports Mole looks at how Thomas Tuchel could set his side up for the contest.
PSG will be without Adrien Rabiot for this weekend's match after he picked up his third yellow card in less than 10 Ligue 1 games, which could see Marquinhos drafted in as a defensive midfielder alongside Marco Verratti.
The front four go into the match in good form having all got on the scoresheet against Red Star Belgrade in midweek, including a stunning hat-trick for Neymar.
Indeed, such was the level of their performance against the Serbian outfit that Rabiot's absence could be the only change Tuchel is forced into making this weekend.
Alphonse Areola and Gianluigi Buffon continue to play tug-of-war with the goalkeeper's jersey, but Areola has been the preferred choice over the past week or so and will hope to retain the gloves again on Sunday.