The French giants lost 2-1 at the Parc des Princes on Wednesday night to see their 49-match domestic unbeaten run come to an end.
Attention now switches back to the league following a three-week break, and manager Thomas Tuchel has a few selection calls to make.
Ahead of Saturday's clash, Sports Mole look at how the perennial champions could line up.
Tuchel fielded a fairly strong side for the quarter-final clash with Guingamp, with Edinson Cavani, Marco Verratti and Dani Alves all coming off the bench to join the likes of Neymar and Kylian Mbappe on the field.
Diarra is believed to be on the brink of retiring from football and Rabiot appears to be on the brink of an exit, so both men will remain absent this weekend, as will Kimpembe after injuring his groin.
Elsewhere, Julian Draxler is in contention for a central-midfield berth after starting five of PSG's last six games either side of the winter break.