The home side suffered a narrow 1-0 defeat to Vancouver Whitecaps in their first league game, while Houston got off to a winning start with a 2-1 home victory over San Jose Earthquakes.
Portland Timbers started their MLS campaign with a disappointing defeat last time out, as they lost 1-0 to Vancouver Whitecaps in Utah.
In a quiet match, Lucas Cavallini netted the only goal soon after half time to take home all three points for the Blue-and-White.
However, they enjoyed an important win before that, as they progressed through the CONCACAF Champions League round of 16 with a 7-2 aggregate victory over Honduran outfit CD Marathon.
The Timbers took home a 2-2 draw from the first leg in Honduras, before they recorded a dominant victory in the home leg, with Yimmi Chara netting a hat-trick alongside goals from Diego Valeri and Marvin Loria.
While they return to continental action on Thursday in the quarter-final, Giovanni Savarese's side will be focussed on Sunday's MLS game, as they look to put their first win on the board.
Their opponents recorded their first victory of the season on the opening day, defeating San Jose Earthquakes 2-1 in Houston.
Tab Ramos's side will be hoping to improve on last season's poor domestic campaign, as they finished bottom of the MLS Western Conference with 21 points from 23 games.
That opening win has definitely set the Texan outfit up in the correct way for this season, and they will look to build on that on Sunday, with the hope of kicking the season off with back-to-back victories.
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Portland Timbers will be without defender Ismaila Jome, after he suffered a season-ending Achilles tendon injury in training on Monday following the defeat to Vancouver at the weekend.
Felipe Mora will lead the line following his permanent switch from UNAM Pumas in January.
He will be supported by the attacking threat of Yimmi Chara, who netted a hat-trick in the second-leg victory over Marathon.
Midfielder Diego Chara played in the game against Vancouver, meaning he has now featured in 11 consecutive MLS seasons for the Timbers.
Maximiliano Urruti opened his account for the season in that game, and he will lead the line again on Sunday.
Portland Timbers possible starting lineup:
Clark; Van Rankin, Mabiala, Zuparic, Bravo; Williamson, D. Chara; Y. Chara, Valeri, Asprilla; Mora
Houston Dynamo possible starting lineup:
Maric; Valentin, Parker, Garcia, Lundqvist; Vera, Rodriguez, Corona; Picault, Urruti, Pasher
We say: Portland Timbers 2-1 Houston Dynamo
Despite their contrasting starts to the season, we see the Timbers coming out of this game with a victory.
They will be hoping to hit a good run of form with their CONCACAF Champions League quarter-final looming, and they should build confidence with a win on Sunday.