"I am grateful to Oxford United for having given me this great opportunity, and cannot wait to get started," Waddock told the club's official website following his appointment. "The club is in a good position, and the immediate priority is to turn that position into promotion at the end of the season.
"In the medium term, the board's vision is to build on the solid platform that has been put together to take Oxford back up the leagues, where a club of this size belongs.
"I applied for this job because I believe that I can be a part of achieving that ambition, and because I fully buy into the board's philosophy of how a football club should be run."
Mickey Lewis had been in control of the League Two side since Wilder departed for Northampton Town in January.