Cadiz secured promotion back to this level courtesy finishing second in the Segunda Division last term, while Osasuna enjoyed an impressive 2019-20 campaign, claiming 10th spot in the table.
Cadiz were regulars in Spain's top flight between 1981 and 1993 but have largely been a second-tier or third-tier side since, only playing one season of La Liga football since the end of the 1992-93 campaign.
El Submarino Amarillo secured a return to this level courtesy of finishing second in the Segunda Division last term, collecting 69 points from their 42 matches to claim the spot behind champions Huesca.
Veteran striker Alvaro Negredo has also joined the club on a free transfer, and it will be fascinating to see how the 34-year-old performs as he prepares to play another campaign of La Liga football.
Osasuna, meanwhile, were excellent in Spain's top flight last term, securing 10th position in the table on their return to this level after two seasons in the Segunda Division.
Jagoba Arrasate's side were actually only four points off finishing in a Europa League position, and it will be fascinating to see whether they can repeat their success in the coming season.
Dating back to June 24, Osasuna have won five of their last eight La Liga matches, suffering just one defeat, while they have won two of their four friendly matches this summer.
Cadiz pre-season form: LWW
Osasuna pre-season form: WWDL
Former Manchester City forward Negredo is expected to lead the line for the newly-promoted outfit, while 41-year-old Alberto Cifuentes should make his La Liga debut between the sticks.
Gallego should shake off a knock to make his debut alongside Adrian Lopez in attack, though, with Torro also potentially earning a starting role in the middle of the park.
Cadiz possible starting lineup:
Cifuentes; Akapo, Lopez, Cala, Espino; Fernandez, Mari, Bodiger; Salvi, Negredo, Malbasic
Osasuna possible starting lineup:
Herrera; Vidal, U Garcia, Hernandez, Perez; Torres, Torro, Oier, D Garcia; Adrian, Gallego
We say: Cadiz 1-2 Osasuna
Cadiz have been handed a tough start as Osasuna proved their class during the 2019-20 campaign. The hosts will be determined to start their campaign with a strong result, but we fancy Osasuna to claim all three points on Saturday night courtesy of a narrow success.