Despite having sold star man Adam Armstrong, Blackburn make the trip to the City Ground after claiming four points from games with Swansea City and Millwall.
On the back of last season's disappointing results, Forest supporters would have been relatively confident about picking up points from fixtures against Coventry City and Bournemouth.
However, back-to-back 2-1 defeats have left Forest as one of just two clubs still looking for their first point in the Championship, keeping the pressure on Chris Hughton.
The fact that no team possesses a 100% record in the division means that the East Midlands outfit are effectively just one win from making significant progress up the table.
Nevertheless, Forest have been left to focus on playing one game at a time during a period where Hughton and the club's owners will be looking to attract new signings.
Like at Forest, fans of Blackburn have had to endure a quiet summer in the transfer market, a consequence of Armstrong's big-money exit not taking place until last week.
That said, Tony Mowbray now has funds to improve a squad of players which have already collected four points from fixtures where they were the clear underdogs.
The point at Millwall was all the more impressive through Blackburn being second best at The Den, a quality which Mowbray will hope stands his side in good stead going forward.
Having opted for a lack of rotation during the EFL Cup, many members of Mowbray's squad will be playing their fourth game in just 11 days on Wednesday night.
Mowbray must decide whether to stick with the 3-5-2 formation which he used during the second half against Millwall.
Liverpool loanee Leighton Clarkson is expected to be named on the substitutes' bench.
Forest will remain without Gaetan Bong as the left-back continues his suspension for violent conduct against Coventry.
Cafu may also be preferred in midfield if Hughton opts to introduce fresh legs.
Nottingham Forest possible starting lineup:
Samba; Lawrence-Gabriel, McKenna, Figueiredo, Osei-Tutu; Yates, Cafu; Mighten, Johnson, Zinckernagel; Grabban
Blackburn Rovers possible starting lineup:
Kaminski; Ayala, Lenihan, Carter; Nyambe, Buckley, Rothwell, Travis, Pickering; Brereton Diaz, Dolan
We say: Nottingham Forest 2-1 Blackburn Rovers
Despite their recent defeats, Forest can claim that luck has gone against them in both fixtures.
With that in mind, we feel that Hughton's side will finally get a win on the board on Wednesday night, outlasting a Blackburn side that did not rotate in the EFL Cup last week.