The Magpies defender, who has missed the last four games with a foot injury, is available once again, as is winger Atsu after shaking off a groin problem.
Newcastle manager Rafael Benitez has made three changes in total from the side that lost 3-1 at Chelsea last Saturday.
Full-back Paul Dummett, who has not played since damaging a hamstring on the opening day of the season, remains unavailable despite stepping up his rehabilitation in recent days.
Leicester, meanwhile, name an unchanged side from the one that started their 1-0 victory over Burnley last weekend.
Newcastle United: Darlow; Yedlin, Clark, Lejeune; Manquillo, Ritchie, Merino, Hayden; Murphy, Gayle, Joselu
Subs: Elliot, Lascelles, Shelvey, Diame, Atsu, Perez, Mitrovic
Leicester City: Schmeichel; Simpson, Maguire, Morgan, Chilwell; Mahrez, Iborra, Ndidi, Albrighton; Gray, Vardy
Subs: Hamer, Fuchs, Dragovic, King, Ulloa, Okazaki, Iheanacho