The defender has recently been out of action after he was hospitalised by a challenge from Wigan Athletic forward Callum McManaman.
Newcastle come into the match looking to overturn a 3-1 deficit from last week's first leg in Portugal.
Newcastle: Krul; Simpson, Yanga-Mbiwa, Williamson, Haidara, Anita, Bigirimana; Cabaye, Sissoko, Gutierrez; Cisse
Subs: Elliot, Perch, Marveaux, Ben Arfa, Gosling, Campbell, Shola Ameobi
Benfica Artur; Luisao, Garay, Andre Almeida; Gaitan, Matic, Perez, Lima, John; Salvio, Melgarejo