The duo will be supported by playmaker Marek Hamsik just behind them, with Gokhan Inler and Valon Behrami as the two central midfielders.
Christian Maggio and Juan Zuniga will be the two wingbacks for Walter Mazzarri's side.
Visitors Lazio will have German striker Miroslav Klose as their main forward, with Hernanes deployed as the playmaker-in-chief.
Napoli: De Sanctis, Campagnaro, Cannavaro, Gamberini, Maggio, Hamsik, Zuniga, Behrami, Inler, Cavani, Pandev
Lazio: Marchetti, Ciani, Dias, Konko, Cavanda, Mauri, Hernanes, Lulic, Ledesma, Candreva, Klose