The Azzurri travel to Tuscany sitting second in Serie A after winning seven of their first nine league games under the Spaniard's guidance.
Benitez believes that La Viola will represent a "significant" examination of Napoli's Scudetto ambitions, while signalling out Colombian winger Juan Cuadrado for special praise.
He told reporters at his pre-match press conference: "They are a difficult side to take on. We will have to keep an eye on Juan Cuadrado, but we will not be man-marking him.
"It is a game that is worth three points like all the others, but it is a significant game as it is between two sides who are high in the standings.
"They are good in possession and they can score goals in numerous ways. We too keep hold of the ball so we'll have to wait and see who controls the game. But the defensive side of the match will be important too."