The Crocodiles stuffed Brest 4-0 last weekend to lead the way at the summit on goal difference, while Nantes played out a goalless draw at Bordeaux.
As one of only four winners on the opening weekend of action, Jerome Arpinon's side sit top of the pile thanks to a superior goal difference on Lorient, Nice and Angers.
Staying anywhere near that position is highly unlikely, of course, with Nimes finishing the shortened 2019-20 season down in 18th place.
After narrowly avoiding the drop last time out, new boss Arpinon's aim this time around will be to ensure that Nimes remain in the top flight for another campaign.
However, the Crocodiles only won back-to-back matches once in the whole of last season and they have a poor away record, losing seven of their last eight on their travels.
Nantes have won eight of their last 10 home matches against Nimes in Ligue 1, but they have won just one of their last nine home league games overall.
This is just their second game of the new campaign, though, and there were positives to take from last week's stalemate against Bordeaux, who had a man sent off in the first half.
The Canaries finished 13th on a points-per-game basis in 2019-20, winning just one of their last eight matches before the campaign was curtailed by the coronavirus crisis.
Scoring goals is proving to be an issue for them, having failed to find the net in their last three Ligue 1 matches - as many blanks as in their previous 14 games.
By comparison, opponents Nimes have scored in nine Ligue 1 matches in a row, which is their longest run since August-October 1979.
Nantes' Ligue 1 form: D
Nimes' Ligue 1 form: W
Three of Nantes' 11 goals in Ligue 1 this calendar year have been goals scored by opponents, making 'own goal' their joint-top scorer in 2020.
Arpinon may therefore be tempted to go with an unchanged XI on the back of the comprehensive win over Brest.
Nantes possible starting lineup:
Lafont; Fabio, Girotto, Pallois, Traore; Blas, Chirivella; Bamba, Louza, Simon; Coulibaly
Nimes possible starting lineup:
Reynet; Ripart, Landre, Martinez, Meling; Deaux, Cubas; Ferhat, Benrahou, Philippoteaux; Denkey
We say: Nantes 0-1 Nimes
Nantes have a good home record against Nimes in recent times, but the visitors enter this game on a real high and, unlike their opponents, are able to find the net. With that in mind, we are backing Arpinon's men to edge this contest.