With three games of the domestic season left to play, the hosts find themselves six points adrift of automatic safety, while Benfica will look to pile pressure on second-placed Porto, as they aim to snatch the spot and achieve Champions League qualification for the next campaign.
Nacional come into this game on the back of a seemingly impressive 2-2 draw away against ninth-placed Moreirense, although a closer look suggests otherwise.
Os Alvinegros took the lead on two separate occasions through a Filipe Soares own goal and a Bryan Rochez strike, but a Nahuel Ferraresi goal and a late Andre Luis equaliser forced Nacional to settle for a point.
That followed a 2-0 defeat to league leaders Sporting Lisbon and a 1-0 victory over sixth-placed Vitoria de Guimaraes, breaking a run of 10 consecutive defeats in the Primeira Liga.
That poor run saw the Madeira outfit drop from a comfortable mid-table position to the foot of the table, now sitting five points behind Boavista in the relegation playoff place and six points adrift of automatic safety.
With nine points left to play for, Manuel Machado's side will know that draws are not sufficient if they are to overcome the odds and avoid the drop, and they will be desperate to pick up just a second win since February to keep their chances alive.
They face a very tough test on Tuesday though, as third-placed Benfica make the trip with second spot in their sights.
Jorge Jesus's side clashed with Porto in the famous O Classico last time out, and they came away with a point.
While it is by no means a devastating result, that outcome did hugely favour Porto, as Benfica now have to overcome a four-point gap in three matches if they are to seal second spot.
They will be encouraged by their run of form though, having won 10 of their last 12 matches in all competitions, including five consecutive victories away from home, only dropping points in that recent draw and in a surprise 2-1 defeat at home to Gil Vicente.
Jesus's men will now focus on winning their last three games to give themselves the best possible chance of creeping into the top two at the end of the season.
Nacional come into this came without centre-back Pedrao, who will serve a suspension after he picked up his 10th yellow card of the season in the recent draw with Moreirense.
However, they will be boosted by the return of midfielder Abdullahi Ibrahim Alhassan, who served a suspension last time out for a red card shown in the defeat to Sporting Lisbon.
Bryan Rochez will be hopeful of a return to the starting side, having come off the bench to net his sixth goal of the season in that recent draw.
Benfica will remain without Jardel, Andre Almeida and Andreas Samaris through injury, while key right-back Diogo Goncalves will serve a suspension after he picked up his fifth yellow card of the season in their draw with Porto.
At the other end of the pitch, the line will be led by Haris Seferovic, who has recorded 18 goals and seven assists in 28 league appearances this season.
He will be supported by Everton, who comes into this game in a strong run of form having hit three goals in the last four games.
Nacional possible starting lineup:
Filipe; Correia, Cesar, Kal; Freitas, Alhassan, Azouni, Vigario; Rochez; Mendez, Riascos
Benfica possible starting lineup:
Leite; Verissimo, Otamendi, Vertonghen; Gilberto, Weigl, Pizzi, Grimaldo; Silva, Seferovic, Everton
We say: Nacional 0-2 Benfica
Although Nacional will come into this game with plenty of desire for a result to keep their survival hopes alive, we do not think they have enough to get past the 37-time Primeira Liga champions on Tuesday.
We see Benfica extending their strong run of form on the road, as they must ensure they win their last three games to keep their chances of a top-two finish alive.