The 23-year-old has already spent a similar spell at Sheffield Wednesday this season, where he featured four times for the Owls.
He returned to Upton Park at the end of September, but he will now spend the next four weeks at the League One outfit.
Spence could make his debut for the MK Dons in their away fixture at Tranmere Rovers on Saturday.
Restore Data
| Team | P | W | D | L | F | A | GD | PTS | |
| 1 | Walsall | 18 | 11 | 4 | 3 | 34 | 19 | 15 | 37 |
| 2 | Port Vale | 19 | 10 | 5 | 4 | 26 | 19 | 7 | 35 |
| 3 | Doncaster RoversDoncaster | 19 | 9 | 6 | 4 | 28 | 22 | 6 | 33 |
| 4 | Crewe AlexandraCrewe | 18 | 8 | 7 | 3 | 22 | 16 | 6 | 31 |
| 5 | Grimsby Town | 19 | 10 | 1 | 8 | 27 | 28 | -1 | 31 |
| 6 | AFC Wimbledon | 18 | 9 | 3 | 6 | 30 | 16 | 14 | 30 |
| 7 | MK Dons | 17 | 9 | 3 | 5 | 30 | 19 | 11 | 30 |
| 8 | Chesterfield | 19 | 7 | 7 | 5 | 33 | 23 | 10 | 28 |
| 9 | Notts County | 18 | 7 | 7 | 4 | 25 | 18 | 7 | 28 |
| 10 | Gillingham | 18 | 8 | 2 | 8 | 19 | 16 | 3 | 26 |
| 11 | Bradford CityBradford | 18 | 6 | 7 | 5 | 23 | 19 | 4 | 25 |
| 12 | Salford City | 18 | 6 | 6 | 6 | 17 | 19 | -2 | 24 |
| 13 | BarrowBarrow | 18 | 6 | 5 | 7 | 18 | 17 | 1 | 23 |
| 14 | Bromley | 18 | 5 | 8 | 5 | 23 | 23 | 0 | 23 |
| 15 | Cheltenham TownCheltenham | 19 | 6 | 5 | 8 | 25 | 28 | -3 | 23 |
| 16 | Fleetwood TownFleetwood | 17 | 5 | 7 | 5 | 23 | 22 | 1 | 22 |
| 17 | Newport CountyNewport | 18 | 6 | 4 | 8 | 21 | 28 | -7 | 22 |
| 18 | Colchester UnitedColchester | 18 | 4 | 9 | 5 | 23 | 22 | 1 | 21 |
| 19 | Harrogate TownHarrogate | 19 | 6 | 3 | 10 | 16 | 28 | -12 | 21 |
| 20 | Accrington StanleyAccrington | 18 | 4 | 6 | 8 | 25 | 33 | -8 | 18 |
| 21 | Tranmere RoversTranmere | 18 | 4 | 6 | 8 | 12 | 25 | -13 | 18 |
| 22 | Swindon TownSwindon | 19 | 3 | 7 | 9 | 23 | 33 | -10 | 16 |
| 23 | Morecambe | 19 | 3 | 5 | 11 | 19 | 34 | -15 | 14 |
| 24 | Carlisle UnitedCarlisle | 18 | 3 | 5 | 10 | 15 | 30 | -15 | 14 |
| > League Two Full Table | |||||||||
