Boro found themselves three goals to the good inside 20 minutes on Saturday after another brace from Duncan Watmore and a smart finish from Marcus Tavernier all but settled the result barely a quarter of the way through the game.
Neil Warnock has since voiced his hopes that Watmore will extend his deal with the Boro, having boosted their goalscoring prowess - something that has been much-needed in recent seasons.
Warnock will hope that he won't have to fight off any competition for the ex-Sunderland man's signature, with a crucial period for recruitment coming in January.
The last meeting between these sides ended in a 1-0 win for the Hatters, but Boro have not lost consecutive league matches against Luton since a run of five in a row between 1961 and 1970, and they will be hoping to come out on top come Wednesday.
Warnock has never lost a league match against Luton since his first season in the Football League in 1987-88, and has only faced Rotherham United more often without losing than he has against the Hatters in his managerial career.
Luton Town and Nathan Jones will head for the Riverside buzzing off the back of an impressive victory on a landmark day for the Hatters
Jones took charge of the Hatters for the 200th time at the weekend, and the 3-0 hammering of Preston brought up his 100th win, with the buoyant boss claiming it as his best.
The Lilywhites were on a high after their midweek victory over Boro but were outplayed by Luton, a side just a point and two places behind Boro in the Championship table and enjoying an impressive season.
Luton are currently the lowest scorers in the top half of the division, and have scored just three goals in their last eight away league matches, suggesting they could face a tall order against the Championship's third-best defence in Boro.
Middlesbrough Championship form: WLWLLW
Luton Town Championship form: DLWLDW
Jones's squad could be bolstered by the return of Croatia international Simon Sluga, who is now back in full training.
The match is likely to come too quickly for striker Danny Hylton, though, who hasn't featured since the defeat against Brentford in October.
Middlesbrough possible starting lineup:
Bettinelli; Dijksteel, Fry, McNair, Bola; Howson, Saville, Morsy, Johnson, Watmore; Assombalonga
Luton Town possible starting lineup:
Shea; Bree, Pearson, Bradley, Lockyer, Norrington-Davies; Morrell, Dewsbury-Hall, Mpanzu; Collins, Lee
We say: Middlesbrough 2-0 Luton Town
Boro have begun to find real momentum at home, winning two of their last three home matches 3-0. Though Luton have been in good form too, we expect Boro to have too much for their mid-table rivals.