Coventry will be looking to put their 4-0 defeat to Blackburn Rovers behind them, while Boro will be hoping to turn draws into wins, after failing to seal three points away to Cardiff City on Saturday.
Middlesbrough have made a strong start to the campaign, but despite this still sit in the bottom half of the table having faced a tough run of fixtures against many of the promotion-chasing teams.
Neil Warnock's return to Cardiff City was not quite the emotional affair many would have expected had fans been present, but Warnock was able to remind his old club of his ability to grind out a result.
Warnock admitted before the game that he was looking forward to his return, but that playing at an empty ground would help him concentrate on trying to beat a Cardiff side he helped build.
Coming off the back of a draw with league-leaders Reading, and then a win against high-flying Bristol City, Boro are evidently a much-improved side this season but were unable to see out the game on Saturday as Cardiff left it late to salvage a point.
If Boro are to fulfil their potential, however, matchups like this one against Coventry will be the type of fixture they will have to win, and Warnock will hope they can claim their third win of the season against the Sky Blues.
Mark Robins's side will need to turn the tide quickly after only securing a point from their last four games, shipping 10 goals in the process, four of which were handed out by Blackburn Rovers on the weekend.
After starting brightly against Blackburn, they hit the self-destruct button when Michael Rose committed a clumsy challenge in the box, receiving a red card and handing Adam Armstrong the opportunity to score his sixth of the season.
The Sky Blues sit 20th in the table and hover precariously above the relegation zone, and many will expect City to play out most of the season at this end of the table.
Robins will need to pick his team up, and quickly, as they now face Boro, the division's in-form team Reading, and fellow strugglers Nottingham Forest in their next three.
Middlesbrough Championship form: DDWDWD
Middlesbrough form (all competitions): DDWDWD
Coventry City Championship form: WDLLDL
Coventry City form (all competitions): WDLLDL
Patrick Roberts could also return to the starting lineup as Warnock may prefer to go with a more attacking outlook against struggling opposition.
Fankaty Dabo is also likely to miss the trip to Middlesbrough after he underwent a small operation that has kept him away from the first-team squad in recent weeks.
Middlesbrough possible starting lineup:
Bettinelli; Dijksteel, Fry, McNair; Howson; Spence, Morsy, Saville, Roberts; Assombalonga; Akpom
Coventry City possible starting lineup:
Marosi; McFadzean, Hyam, Rose; McCallum, Sheaf, Hamer, Giles; Allen, O'Hare; Godden
We say: Middlesbrough 3-0 Coventry City
Warnock's men have shown they can grind out results in recent weeks, but we expect to see a more attacking Boro side this time around, and considering that they face a depleted Coventry side, we cannot see past the Smoggies for this one. We expect Boro to seal their second home win of the season, and inflict further misery on City's poor start.